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Midline crossing and Slit responsiveness of commissural axons require USP33.

ABSTRACT: Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.

SUBMITTER: Yuasa-Kawada J 

PROVIDER: S-EPMC3893063 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Midline crossing and Slit responsiveness of commissural axons require USP33.

Yuasa-Kawada Junichi J   Kinoshita-Kawada Mariko M   Wu Guan G   Rao Yi Y   Wu Jane Y JY  

Nature neuroscience 20090816 9

Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling. ...[more]

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