Ontology highlight
ABSTRACT:
SUBMITTER: Evans TA
PROVIDER: S-EPMC4505356 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
eLife 20150717
During nervous system development, commissural axons cross the midline despite the presence of repellant ligands. In Drosophila, commissural axons avoid premature responsiveness to the midline repellant Slit by expressing the endosomal sorting receptor Commissureless, which reduces surface expression of the Slit receptor Roundabout1 (Robo1). In this study, we describe a distinct mechanism to inhibit Robo1 repulsion and promote midline crossing, in which Roundabout2 (Robo2) binds to and prevents ...[more]