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Trials and tribulations of skin iontophoresis in therapeutics.

ABSTRACT: Iontophoresis is a method of non-invasive transdermal drug delivery based on the transfer of charged molecules using a low-intensity electric current. Both local and systemic administration are possible; however, the skin pharmacokinetics of iontophoretically delivered drugs is complex and difficult to anticipate. The unquestionable theoretical advantages of the technique make it attractive in several potential applications. After a brief review of the factors influencing iontophoresis, we detail the current applications of iontophoresis in therapeutics and the main potential applications under investigation, including systemic and topical drugs and focusing on the treatment of scleroderma-related ulcerations. Finally, we address the issue of safety, which could be a limitation to the routine clinical use of iontophoresis.

SUBMITTER: Roustit M

PROVIDER: S-EPMC3895348 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Trials and tribulations of skin iontophoresis in therapeutics.

Roustit Matthieu M Blaise Sophie S Cracowski Jean-Luc JL

British journal of clinical pharmacology 20140101 1

Iontophoresis is a method of non-invasive transdermal drug delivery based on the transfer of charged molecules using a low-intensity electric current. Both local and systemic administration are possible; however, the skin pharmacokinetics of iontophoretically delivered drugs is complex and difficult to anticipate. The unquestionable theoretical advantages of the technique make it attractive in several potential applications. After a brief review of the factors influencing iontophoresis, we detai ...[more]

PMID: 23590287

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Trials and tribulations of skin iontophoresis in therapeutics.

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Trials and tribulations of skin iontophoresis in therapeutics.

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