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HIV-1 Eradication: Early Trials (and Tribulations).

ABSTRACT: Antiretroviral therapy (ART) has rendered HIV-1 infection a manageable illness for those with access to treatment. However, ART does not lead to viral eradication owing to the persistence of replication-competent, unexpressed proviruses in long-lived cellular reservoirs. The potential for long-term drug toxicities and the lack of access to ART for most people living with HIV-1 infection have fueled scientific interest in understanding the nature of this latent reservoir. Exploration of HIV-1 persistence at the cellular and molecular level in resting memory CD4(+) T cells, the predominant viral reservoir in patients on ART, has uncovered potential strategies to reverse latency. We review recent advances in pharmacologically based 'shock and kill' HIV-1 eradication strategies, including comparative analysis of early clinical trials.

SUBMITTER: Spivak AM

PROVIDER: S-EPMC5889129 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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HIV-1 Eradication: Early Trials (and Tribulations).

Spivak Adam M AM Planelles Vicente V

Trends in molecular medicine 20151212 1

Antiretroviral therapy (ART) has rendered HIV-1 infection a manageable illness for those with access to treatment. However, ART does not lead to viral eradication owing to the persistence of replication-competent, unexpressed proviruses in long-lived cellular reservoirs. The potential for long-term drug toxicities and the lack of access to ART for most people living with HIV-1 infection have fueled scientific interest in understanding the nature of this latent reservoir. Exploration of HIV-1 per ...[more]

PMID: 26691297

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Dataset Information

HIV-1 Eradication: Early Trials (and Tribulations).

Publications

HIV-1 Eradication: Early Trials (and Tribulations).

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