Ontology highlight
ABSTRACT:
SUBMITTER: Meng W
PROVIDER: S-EPMC3906580 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Frontiers in immunology 20140130
VH replacement (VHR) is a type of antibody gene rearrangement in which an upstream heavy chain variable gene segment (VH) invades a pre-existing rearrangement (VDJ). In this Hypothesis and Theory article, we begin by reviewing the mechanism of VHR, its developmental timing and its potential biological consequences. Then we explore the hypothesis that specific sequence motifs called footprints reflect VHR versus other processes. We provide a compilation of footprint sequences from different regio ...[more]