Trials and Tribulations with VH Replacement.
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ABSTRACT:
SUBMITTER: Meng W
PROVIDER: S-EPMC3906580 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Trials and Tribulations with VH Replacement.
Meng Wenzhao W Jayaraman Sahana S Zhang Bochao B Schwartz Gregory W GW Daber Robert D RD Hershberg Uri U Garfall Alfred L AL Carlson Christopher S CS Luning Prak Eline T ET
Frontiers in immunology 20140130
VH replacement (VHR) is a type of antibody gene rearrangement in which an upstream heavy chain variable gene segment (VH) invades a pre-existing rearrangement (VDJ). In this Hypothesis and Theory article, we begin by reviewing the mechanism of VHR, its developmental timing and its potential biological consequences. Then we explore the hypothesis that specific sequence motifs called footprints reflect VHR versus other processes. We provide a compilation of footprint sequences from different regio ...[more]
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