Ontology highlight
ABSTRACT:
SUBMITTER: Tarantino N
PROVIDER: S-EPMC3897181 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Tarantino Nadine N Tinevez Jean-Yves JY Crowell Elizabeth Faris EF Boisson Bertrand B Henriques Ricardo R Mhlanga Musa M Agou Fabrice F Israël Alain A Laplantine Emmanuel E
The Journal of cell biology 20140101 2
Nuclear factor κB (NF-κB) essential modulator (NEMO), a regulatory component of the IκB kinase (IKK) complex, controls NF-κB activation through its interaction with ubiquitin chains. We show here that stimulation with interleukin-1 (IL-1) and TNF induces a rapid and transient recruitment of NEMO into punctate structures that are anchored at the cell periphery. These structures are enriched in activated IKK kinases and ubiquitinated NEMO molecules, which suggests that they serve as organizing cen ...[more]