Ontology highlight
ABSTRACT:
SUBMITTER: Nakamori Y
PROVIDER: S-EPMC2063884 | biostudies-other | 2006 Jun
REPOSITORIES: biostudies-other
Nakamori Yoshitaka Y Emoto Masahiro M Fukuda Naofumi N Taguchi Akihiko A Okuya Shigeru S Tajiri Michiko M Miyagishi Makoto M Taira Kazunari K Wada Yoshinao Y Tanizawa Yukio Y
The Journal of cell biology 20060601 5
Tumor necrosis factor-alpha (TNF-alpha) signaling through the IkappaB kinase (IKK) complex attenuates insulin action via the phosphorylation of insulin receptor substrate 1 (IRS-1) at Ser307. However, the precise molecular mechanism by which the IKK complex phosphorylates IRS-1 is unknown. In this study, we report nuclear factor kappaB essential modulator (NEMO)/IKK-gamma subunit accumulation in membrane ruffles followed by an interaction with IRS-1. This intracellular trafficking of NEMO requir ...[more]