Ontology highlight
ABSTRACT:
SUBMITTER: Chen JY
PROVIDER: S-EPMC3897208 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Chen Jia-Yun JY Lin Jia-Ren JR Cimprich Karlene A KA Meyer Tobias T
Molecular cell 20111228 2
Growth factors activate Ras, PI3K, and other signaling pathways. It is not well understood how these signals are translated by individual cells into a decision to proliferate or differentiate. Here, using single-cell image analysis of nerve growth factor (NGF)-stimulated PC12 cells, we identified a two-dimensional phospho-ERK (pERK)-phospho-AKT (pAKT) response map with a curved boundary that separates differentiating from proliferating cells. The boundary position remained invariant when differe ...[more]