Ontology highlight
ABSTRACT:
SUBMITTER: Mojtahedi M
PROVIDER: S-EPMC5189937 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Mojtahedi Mitra M Skupin Alexander A Zhou Joseph J Castaño Ivan G IG Leong-Quong Rebecca Y Y RY Chang Hannah H Trachana Kalliopi K Giuliani Alessandro A Huang Sui S
PLoS biology 20161227 12
Cell fate choice and commitment of multipotent progenitor cells to a differentiated lineage requires broad changes of their gene expression profile. But how progenitor cells overcome the stability of their gene expression configuration (attractor) to exit the attractor in one direction remains elusive. Here we show that commitment of blood progenitor cells to the erythroid or myeloid lineage is preceded by the destabilization of their high-dimensional attractor state, such that differentiating c ...[more]