Ontology highlight
ABSTRACT:
SUBMITTER: Tretter T
PROVIDER: S-EPMC3897919 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Tretter Thomas T Pereira Fábio P FP Ulucan Ozlem O Helms Volkhard V Allan Susanne S Kalies Kai-Uwe KU Römisch Karin K
BMC cell biology 20131206
<h4>Background</h4>The Sec61 channel mediates protein translocation across the endoplasmic reticulum (ER) membrane during secretory protein biogenesis, and likely also during export of misfolded proteins for ER-associated degradation (ERAD). The mechanisms of channel opening for the different modes of translocation are not understood so far, but the position of the large ER-lumenal loop 7 of Sec61p suggests a decisive role.<h4>Results</h4>We show here that the Y345H mutation in L7 which causes d ...[more]