Ontology highlight
ABSTRACT:
SUBMITTER: Hajdu P
PROVIDER: S-EPMC3900865 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Hajdu Péter P Chimote Ameet A AA Thompson Tyler H TH Koo Youngmi Y Yun Yeoheung Y Conforti Laura L
Biomaterials 20130927 38
Effector memory T cells (TM) play a key role in the pathology of certain autoimmune disorders. The activity of effector TM cells is under the control of Kv1.3 ion channels, which facilitate the Ca(2+) influx necessary for T cell activation and function, i.e. cytokine release and proliferation. Consequently, the knock-down of Kv1.3 expression in effector TM's may be utilized as a therapy for the treatment of autoimmune diseases. In this study we synthesized lipid unilamellar nanoparticles (NPs) t ...[more]