Polymorphisms in DNA repair pathway genes, body mass index, and risk of non-Hodgkin lymphoma.

ABSTRACT: We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ?25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P?=?0.004) for T-cell lymphoma and ERCC2 (rs13181; P?=?0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk.

SUBMITTER: Chen Y 

PROVIDER: S-EPMC3902049 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature