Ontology highlight
ABSTRACT:
SUBMITTER: McIntyre BA
PROVIDER: S-EPMC3902293 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
McIntyre Brendan A S BA Alev Cantas C Mechael Rami R Salci Kyle R KR Lee Jung Bok JB Fiebig-Comyn Aline A Guezguez Borhane B Wu Yuping Y Sheng Guojun G Bhatia Mickie M
Stem cells translational medicine 20131203 1
Production of human embryonic stem cell (hESC)-derived lung progenitors has broad applicability for drug screening and cell therapy; however, this is complicated by limitations in demarcating phenotypic changes with functional validation of airway cell types. In this paper, we reveal the potential of hESCs to produce multipotent lung progenitors using a combined growth factor and physical culture approach, guided by the use of novel markers LIFRα and NRP1. Lung specification of hESCs was achieve ...[more]