Ontology highlight
ABSTRACT:
SUBMITTER: Lu SJ
PROVIDER: S-EPMC3766360 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Lu Shi-Jiang SJ Feng Qiang Q Caballero Sergio S Chen Yu Y Moore Malcolm A S MA Grant Maria B MB Lanza Robert R
Nature methods 20070507 6
Recent evidence suggests the existence of progenitor cells in adult tissues that are capable of differentiating into vascular structures as well as into all hematopoietic cell lineages. Here we describe an efficient and reproducible method for generating large numbers of these bipotential progenitors-known as hemangioblasts-from human embryonic stem (hES) cells using an in vitro differentiation system. Blast cells expressed gene signatures characteristic of hemangioblasts, and could be expanded, ...[more]