Ontology highlight
ABSTRACT:
SUBMITTER: Castelli M
PROVIDER: S-EPMC3906245 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Castelli Marilena M Piobbico Danilo D Bartoli Daniela D Pieroni Stefania S Brunacci Cinzia C Bellet Marina Maria MM Chiacchiaretta Martina M Della Fazia Maria Agnese MA Servillo Giuseppe G
Cell cycle (Georgetown, Tex.) 20130201 2
Hepatocyte odd protein shuttling (HOPS) moves between nucleus and cytoplasm. HOPS overexpression leads to cell cycle arrest in G 0/G 1, and HOPS knockdown causes centrosome alterations, with subsequent abnormal cell division. Recently, we demonstrated that HOPS acts as a functional bridge in NPM-p19(Arf) interactions. Here we show that HOPS is present in 3 different isoforms that play distinct intracellular functions. Although HOPS is a transmembrane ubiquitin, an isoform with intermediate molec ...[more]