Ontology highlight
ABSTRACT:
SUBMITTER: Wei J
PROVIDER: S-EPMC3911114 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Wei Junhong J Tian Yuqing Y Niu Guoqing G Tan Huarong H
Applied and environmental microbiology 20131115 2
Gougerotin is a peptidyl nucleoside antibiotic. It functions as a specific inhibitor of protein synthesis by binding ribosomal peptidyl transferase and exhibits a broad spectrum of biological activities. gouR, situated in the gougerotin biosynthetic gene cluster, encodes a TetR family transcriptional regulatory protein. Gene disruption and genetic complementation revealed that gouR plays an important role in the biosynthesis of gougerotin. Transcriptional analysis suggested that GouR represses t ...[more]