Ontology highlight
ABSTRACT:
SUBMITTER: Biosse Duplan M
PROVIDER: S-EPMC3911273 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Biosse Duplan Martin M Zalli Detina D Stephens Sebastien S Zenger Serhan S Neff Lynn L Oelkers J Margit JM Lai Frank P L FP Horne William W Rottner Klemens K Baron Roland R
Molecular and cellular biology 20131021 1
In osteoclasts (OCs) podosomes are organized in a belt, a feature critical for bone resorption. Although microtubules (MTs) promote the formation and stability of the belt, the MT and/or podosome molecules that mediate the interaction of the two systems are not identified. Because the growing "plus" ends of MTs point toward the podosome belt, plus-end tracking proteins (+TIPs) might regulate podosome patterning. Among the +TIPs, EB1 increased as OCs matured and was enriched in the podosome belt, ...[more]