Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5039685 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Zhang Yijun Y Luo Youguang Y Lyu Rui R Chen Jie J Liu Ruming R Li Dengwen D Liu Min M Zhou Jun J
Theranostics 20160912 12
Cell migration, a complex process critical for tumor progression and metastasis, requires a dynamic crosstalk between microtubules (MTs) and focal adhesions (FAs). However, the molecular mechanisms underlying this event remain elusive. Herein we identify the proto-oncogenic protein Src as an important player in the regulation of the MT-FA crosstalk. Src interacts with and phosphorylates end-binding protein 1 (EB1), a member of MT plus end-tracking proteins (+TIPs), both in cells and <i>in vitro< ...[more]