Ontology highlight
ABSTRACT:
SUBMITTER: Kim SY
PROVIDER: S-EPMC3911500 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Kim So Yong SY Baik Kyung-Hwa KH Baek Kwan-Hyuck KH Chah Kyong-Hwa KH Kim Kyung Ah KA Moon Gyuyoung G Jung Eunyu E Kim Seong-Tae ST Shim Jae-Hyuck JH Greenblatt Matthew B MB Chun Eunyoung E Lee Ki-Young KY
Molecular and cellular biology 20131125 3
Transforming growth factor β (TGF-β)-activated kinase 1 (TAK1) is a key regulator in the signals transduced by proinflammatory cytokines and Toll-like receptors (TLRs). The regulatory mechanism of TAK1 in response to various tissue types and stimuli remains incompletely understood. Here, we show that ribosomal S6 kinase 1 (S6K1) negatively regulates TLR-mediated signals by inhibiting TAK1 activity. S6K1 overexpression causes a marked reduction in NF-κB and AP-1 activity induced by stimulation of ...[more]