Ontology highlight
ABSTRACT:
SUBMITTER: Niewiadomski P
PROVIDER: S-EPMC3915062 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Cell reports 20131227 1
Gli proteins are transcriptional effectors of the Hedgehog (Hh) pathway in both normal development and cancer. We describe a program of multisite phosphorylation that regulates the conversion of Gli proteins into transcriptional activators. In the absence of Hh ligands, Gli activity is restrained by the direct phosphorylation of six conserved serine residues by protein kinase A (PKA), a master negative regulator of the Hh pathway. Activation of signaling leads to a global remodeling of the Gli p ...[more]