Ontology highlight
ABSTRACT:
SUBMITTER: Kong JH
PROVIDER: S-EPMC6550017 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20190515 10
Signaling pathways that mediate cell-cell communication are essential for collective cell behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and elucidated in <i>Drosophila</i>, is one of these iconic signaling systems that plays many roles during embryogenesis and in adults; abnormal HH signaling can lead to birth defects and cancer. We review recent structural and biochemical studies that have advanced our understanding of the vertebrate HH pathway, focusing on the ...[more]