Ontology highlight
ABSTRACT:
SUBMITTER: Inoue S
PROVIDER: S-EPMC3918781 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Inoue Satoshi S Tomasini Richard R Rufini Alessandro A Elia Andrew J AJ Agostini Massimiliano M Amelio Ivano I Cescon Dave D Dinsdale David D Zhou Lily L Harris Isaac S IS Lac Sophie S Silvester Jennifer J Li Wanda Y WY Sasaki Masato M Haight Jillian J Brüstle Anne A Wakeham Andrew A McKerlie Colin C Jurisicova Andrea A Melino Gerry G Mak Tak W TW
Proceedings of the National Academy of Sciences of the United States of America 20140121 5
The generation of viable sperm proceeds through a series of coordinated steps, including germ cell self-renewal, meiotic recombination, and terminal differentiation into functional spermatozoa. The p53 family of transcription factors, including p53, p63, and p73, are critical for many physiological processes, including female fertility, but little is known about their functions in spermatogenesis. Here, we report that deficiency of the TAp73 isoform, but not p53 or ΔNp73, results in male inferti ...[more]