Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC4363142 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Liu Yan Y DeBoer Kathleen K de Kretser David M DM O'Donnell Liza L O'Connor Anne E AE Merriner D Jo DJ Okuda Hidenobu H Whittle Belinda B Jans David A DA Efthymiadis Athina A McLachlan Robert I RI Ormandy Christopher J CJ Goodnow Chris C CC Jamsai Duangporn D O'Bryan Moira K MK
PLoS genetics 20150317 3
Male infertility affects at least 5% of reproductive age males. The most common pathology is a complex presentation of decreased sperm output and abnormal sperm shape and motility referred to as oligoasthenoteratospermia (OAT). For the majority of OAT men a precise diagnosis cannot be provided. Here we demonstrate that leucine-rich repeats and guanylate kinase-domain containing isoform 1 (LRGUK-1) is required for multiple aspects of sperm assembly, including acrosome attachment, sperm head shapi ...[more]