Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.
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ABSTRACT:
SUBMITTER: Calvaresi EC
PROVIDER: S-EPMC3919968 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.
Calvaresi Emilia C EC Granchi Carlotta C Tuccinardi Tiziano T Di Bussolo Valeria V Huigens Robert W RW Lee Hyang Yeon HY Palchaudhuri Rahul R Macchia Marco M Martinelli Adriano A Minutolo Filippo F Hergenrother Paul J PJ
Chembiochem : a European journal of chemical biology 20131031 17
Effective glucose diet: We report the development and activity of glucose-conjugated LDH-A inhibitors designed for dual targeting of the Warburg effect (elevated glucose uptake and glycolysis) in cancer cells. Glycoconjugation could be applied to inhibitors of many enzymes involved in glycolysis or tumor metabolism. ...[more]
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