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A novel indigoid anti-tuberculosis agent.

ABSTRACT: The structure of a novel indigoid component was characterized by X-ray crystallography. This compound exhibited excellent anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv in whole cell culture showing a submicromolar minimum inhibitory concentration (MIC). A synthesis of this molecule was designed and carried out to produce sufficient material for further testing. The in vitro profile, structure, and first synthesis of this indigoid component is reported.

SUBMITTER: Klein LL

PROVIDER: S-EPMC3922930 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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A novel indigoid anti-tuberculosis agent.

Klein Larry L LL Petukhova Valentina V Wan Baojie B Wang Yuehong Y Santasiero Bernard D BD Lankin David C DC Pauli Guido F GF Franzblau Scott G SG

Bioorganic & medicinal chemistry letters 20131121 1

The structure of a novel indigoid component was characterized by X-ray crystallography. This compound exhibited excellent anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv in whole cell culture showing a submicromolar minimum inhibitory concentration (MIC). A synthesis of this molecule was designed and carried out to produce sufficient material for further testing. The in vitro profile, structure, and first synthesis of this indigoid component is reported. ...[more]

PMID: 24314672

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