GlmU inhibitor from the roots of Euphorbia ebracteolata as an anti-tuberculosis agent.

ABSTRACT: At present, the emerging drug-resistance of Mycobacterium tuberculosis (M. tb) against existing frontline drugs has prompted the development of novel anti-tuberculosis agents based on new targets. Activity of the bifunctional enzyme, glucosamine-1-phosphate acetyltransferase activity and N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) is essential for biosynthesis of the mycobacterium cell wall components and has been proposed as a potential drug target for therapeutic interventions. On the basis of the high-throughput screening of the GlmU AT inhibitor, an extract of Euphorbia ehracteolata displayed a significant inhibitory effect among 49 tested herbal medicines. Using the bioassay-guided separation, an aromatic diterpenoid ebractenoid F was identifie

SUBMITTER: Han X 

PROVIDER: S-EPMC9214920 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature