Aggregate-depleted brain fails to induce A? deposition in a mouse model of Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Duran-Aniotz C
PROVIDER: S-EPMC3923072 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Aggregate-depleted brain fails to induce Aβ deposition in a mouse model of Alzheimer's disease.
Duran-Aniotz Claudia C Morales Rodrigo R Moreno-Gonzalez Ines I Hu Ping Ping PP Fedynyshyn Joseph J Soto Claudio C
PloS one 20140212 2
Recent studies in animal models of Alzheimer's disease (AD) show that amyloid-beta (Aβ) misfolding can be transmissible; however, the mechanisms by which this process occurs have not been fully explored. The goal of this study was to analyze whether depletion of aggregates from an AD brain suppresses its in vivo "seeding" capability. Removal of aggregates was performed by using the Aggregate Specific Reagent 1 (ASR1) compound which has been previously described to specifically bind misfolded spe ...[more]
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