Ontology highlight
ABSTRACT:
SUBMITTER: Xia Z
PROVIDER: S-EPMC3923210 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Xia Zhen Z Chen Huabiao H Kang Seung-gu SG Huynh Tien T Fang Justin W JW Lamothe Pedro A PA Walker Bruce D BD Zhou Ruhong R
Scientific reports 20140213
Immune control of viral infections is modulated by diverse T cell receptor (TCR) clonotypes engaging peptide-MHC class I complexes on infected cells, but the relationship between TCR structure and antiviral function is unclear. Here we apply in silico molecular modeling with in vivo mutagenesis studies to investigate TCR-pMHC interactions from multiple CTL clonotypes specific for a well-defined HIV-1 epitope. Our molecular dynamics simulations of viral peptide-HLA-TCR complexes, based on two ind ...[more]