Gametogenesis eliminates age-induced cellular damage and resets life span in yeast.
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ABSTRACT:
SUBMITTER: Unal E
PROVIDER: S-EPMC3923466 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
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Gametogenesis eliminates age-induced cellular damage and resets life span in yeast.
Unal Elçin E Kinde Benyam B Amon Angelika A
Science (New York, N.Y.) 20110601 6037
Eukaryotic organisms age, yet detrimental age-associated traits are not passed on to progeny. How life span is reset from one generation to the next is not known. We show that in budding yeast resetting of life span occurs during gametogenesis. Gametes (spores) generated by aged cells show the same replicative potential as gametes generated by young cells. Age-associated damage is no longer detectable in mature gametes. Furthermore, transient induction of a transcription factor essential for lat ...[more]
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2008-08-01 | GSE8775 | GEO