Ontology highlight
ABSTRACT:
SUBMITTER: Toettcher JE
PROVIDER: S-EPMC3925772 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Toettcher Jared E JE Weiner Orion D OD Lim Wendell A WA
Cell 20131201 6
The complex, interconnected architecture of cell-signaling networks makes it challenging to disentangle how cells process extracellular information to make decisions. We have developed an optogenetic approach to selectively activate isolated intracellular signaling nodes with light and use this method to follow the flow of information from the signaling protein Ras. By measuring dose and frequency responses in single cells, we characterize the precision, timing, and efficiency with which signals ...[more]