Ontology highlight
ABSTRACT:
SUBMITTER: Schlauderer F
PROVIDER: S-EPMC6168461 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Schlauderer Florian F Seeholzer Thomas T Desfosses Ambroise A Gehring Torben T Strauss Mike M Hopfner Karl-Peter KP Gutsche Irina I Krappmann Daniel D Lammens Katja K
Nature communications 20181002 1
The CARD11-BCL10-MALT1 (CBM) complex triggers the adaptive immune response in lymphocytes and lymphoma cells. CARD11/CARMA1 acts as a molecular seed inducing BCL10 filaments, but the integration of MALT1 and the assembly of a functional CBM complex has remained elusive. Using cryo-EM we solved the helical structure of the BCL10-MALT1 filament. The structural model of the filament core solved at 4.9 Å resolution identified the interface between the N-terminal MALT1 DD and the BCL10 caspase recrui ...[more]