Functional Fcgamma receptor polymorphisms are associated with human allergy.

ABSTRACT: IgG Fc receptors (Fc?Rs) play important roles in immune responses. It is not clear whether Fc?R receptors play a role in human asthma and allergy. The aim of current study was to investigate whether functional single nucleotide polymorphisms (SNPs) of Fc?R genes (FCGR) are associated with human asthma and allergy.Functional SNPs of FCGR2A (Fc?RIIA-131His>Arg, rs1801274), FCGR2B (Fc?RIIB-187Ile>Thr, rs1050501), FCGR2C (Fc?RIIC-13Gln>Stop, rs10917661), FCGR3A (Fc?RIIIA-158Val>Phe, rs396991), and FCGR3B variants (Fc?RIIIB NA1 and NA2) were genotyped in an asthma family cohort including 370 atopy positive, 239 atopy negative, and 169 asthma positive subjects. The genotype and phenotype data (asthma, bronchial hyper-responsiveness, and atopy) of subjects were analyzed using family-based association tests (FBAT) and logistic regression adjusted for age and sex.The Fc?RIIA-131His>Arg SNP is significantly associated with atopy in a family-based association test (P = 0.00287) and in a logistic regression analysis (P = 0.0269, OR 0.732, 95% CI: 0.555-0.965). The Fc?RIIA-131His (or rs1801274-A) allele capable of binding human IgG2 has a protective role against atopy. In addition, the rare Fc?RIIB-187Thr (or rs1050501-C) allele defective for the receptor-mediated inhibitory signals is a risk factor for atopy (P = 0.0031, OR 1.758, 95% CI: 1.209-2.556) and IgE production (P<0.001). However, variants of activating Fc?RIIIA (rs396991), and Fc?RIIIB (NA1 and NA2), and Fc?RIIC (rs10917661) are not associated with asthma, BHR, and atopy (P>0.05).Fc?RIIA and Fc?RIIB functional polymorphisms may have a role in the pathogenesis of allergy.

SUBMITTER: Wu J 

PROVIDER: S-EPMC3931680 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature