Ontology highlight
ABSTRACT:
SUBMITTER: Matsui Y
PROVIDER: S-EPMC3936105 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Matsui Yusuke Y Shindo Keisuke K Nagata Kayoko K Io Katsuhiro K Tada Kohei K Iwai Fumie F Kobayashi Masayuki M Kadowaki Norimitsu N Harris Reuben S RS Takaori-Kondo Akifumi A
Virology 20131126
Vif is essential for HIV-1 replication in T cells and macrophages. Vif recruits a host ubiquitin ligase complex to promote proteasomal degradation of the APOBEC3 restriction factors by poly-ubiquitination. The cellular transcription cofactor CBFβ is required for Vif function by stabilizing the Vif protein and promoting recruitment of a cellular Cullin5-RING ubiquitin ligase complex. Interaction between Vif and CBFβ is a promising therapeutic target, but little is known about the interfacial resi ...[more]