Ontology highlight
ABSTRACT:
SUBMITTER: Peng X
PROVIDER: S-EPMC6638891 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Peng Xi X Williams John J Smallwood Philip M PM Nathans Jeremy J
PloS one 20190718 7
The Amyloid Precursor Protein (APP) and Contactin (CNTN) families of cell-surface proteins have been intensively studied in the context of neural development and neuropsychiatric diseases. Earlier studies demonstrated both genetic and biochemical interactions between the extracellular domains of APP and CNTN3, but their precise binding interfaces were not defined. In the present study, we have used binding assays between APP-alkaline phosphatase (AP) fusion proteins and CNTN-Fc fusion proteins, ...[more]