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MRNA 3'end processing: A tale of the tail reaches the clinic.

ABSTRACT: Recent advances reveal mRNA 3'end processing as a highly regulated process that fine-tunes posttranscriptional gene expression. This process can affect the site and/or the efficiency of 3'end processing, controlling the quality and the quantity of substrate mRNAs. The regulation of 3'end processing plays a central role in fundamental physiology such as blood coagulation and innate immunity. In addition, errors in mRNA 3'end processing have been associated with a broad spectrum of human diseases, including cancer. We summarize and discuss the paradigmatic shift in the understanding of 3'end processing as a mechanism of posttranscriptional gene regulation that has reached clinical medicine.

SUBMITTER: Hollerer I

PROVIDER: S-EPMC3936486 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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mRNA 3'end processing: A tale of the tail reaches the clinic.

Hollerer Ina I Grund Kerstin K Hentze Matthias W MW Kulozik Andreas E AE

EMBO molecular medicine 20140101 1

Recent advances reveal mRNA 3'end processing as a highly regulated process that fine-tunes posttranscriptional gene expression. This process can affect the site and/or the efficiency of 3'end processing, controlling the quality and the quantity of substrate mRNAs. The regulation of 3'end processing plays a central role in fundamental physiology such as blood coagulation and innate immunity. In addition, errors in mRNA 3'end processing have been associated with a broad spectrum of human diseases, ...[more]

PMID: 24408965

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