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EGFR: tale of the C-terminal tail.

ABSTRACT: The carboxy terminal tail of epidermal growth factor receptor (EGFR) plays a critical role in the regulation of the enzyme activity of the kinase. There is a good structural model for the mechanism by which the C-terminal tail proximal to the kinase domain contributes to the negative regulation of the activity. Its conformation in the active state, conversely, has remained elusive due to its dynamic nature. A recently published structure of EGFR kinase domain shows the conformation of the proximal C-terminal tail in the active kinase. Analysis of this conformational state of the C-terminal tail is presented, and some of the mutagenesis data is revisited.

SUBMITTER: Gajiwala KS

PROVIDER: S-EPMC3719092 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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EGFR: tale of the C-terminal tail.

Gajiwala Ketan S KS

Protein science : a publication of the Protein Society 20130611 7

The carboxy terminal tail of epidermal growth factor receptor (EGFR) plays a critical role in the regulation of the enzyme activity of the kinase. There is a good structural model for the mechanism by which the C-terminal tail proximal to the kinase domain contributes to the negative regulation of the activity. Its conformation in the active state, conversely, has remained elusive due to its dynamic nature. A recently published structure of EGFR kinase domain shows the conformation of the proxim ...[more]

PMID: 23674349

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