MRNA Display Reaches for the Clinic with New PCSK9 Inhibitor.
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ABSTRACT:
SUBMITTER: Iskandar SE
PROVIDER: S-EPMC9465826 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Publications
mRNA Display Reaches for the Clinic with New PCSK9 Inhibitor.
Iskandar Sabrina E SE Bowers Albert A AA
ACS medicinal chemistry letters 20220826 9
Merck & Co. recently reported one of the first mRNA display-derived clinical candidates in a bioavailable inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9). Herein, we discuss the chemical and pharmacological challenges surmounted in bringing this compound to trials and the current outlook for mRNA display-based therapeutic development. ...[more]
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