Ontology highlight
ABSTRACT:
SUBMITTER: Dalli J
PROVIDER: S-EPMC3936490 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Dalli Jesmond J Norling Lucy V LV Montero-Melendez Trinidad T Federici Canova Donata D Lashin Hazem H Pavlov Anton M AM Sukhorukov Gleb B GB Hinds Charles J CJ Perretti Mauro M
EMBO molecular medicine 20131215 1
Incorporation of locally produced signaling molecules into cell-derived vesicles may serve as an endogenous mediator delivery system. We recently reported that levels alpha-2-macroglobulin (A2MG)-containing microparticles are elevated in plasma from patients with sepsis. Herein, we investigated the immunomodulatory actions of A2MG containing microparticles during sepsis. Administration of A2MG-enriched (A2MG-E)-microparticles to mice with microbial sepsis protected against hypothermia, reduced b ...[more]