Ontology highlight
ABSTRACT:
SUBMITTER: Ishikawa H
PROVIDER: S-EPMC3936765 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Ishikawa Hideaki H Nobe Yuko Y Izumikawa Keiichi K Yoshikawa Harunori H Miyazawa Naoki N Terukina Goro G Kurokawa Natsuki N Taoka Masato M Yamauchi Yoshio Y Nakayama Hiroshi H Isobe Toshiaki T Takahashi Nobuhiro N
Nucleic acids research 20131205 4
The U1 small nuclear ribonucleoprotein (snRNP) plays pivotal roles in pre-mRNA splicing and in regulating mRNA length and isoform expression; however, the mechanism of U1 snRNA quality control remains undetermined. Here, we describe a novel surveillance pathway for U1 snRNP biogenesis. Mass spectrometry-based RNA analysis showed that a small population of SMN complexes contains truncated forms of U1 snRNA (U1-tfs) lacking the Sm-binding site and stem loop 4 but containing a 7-monomethylguanosine ...[more]