Ontology highlight
ABSTRACT:
SUBMITTER: Kattner C
PROVIDER: S-EPMC3943661 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Kattner Christof C Toussi Deana N DN Zaucha Jan J Wetzler Lee M LM Rüppel Nadine N Zachariae Ulrich U Massari Paola P Tanabe Mikio M
Journal of structural biology 20131219 3
Among all Neisseriae species, Neisseria meningitidis and Neisseria gonorrhoeae are the only human pathogens, causative agents of bacterial meningitis and gonorrhoea, respectively. PorB, a pan-Neisseriae trimeric porin that mediates diffusive transport of essential molecules across the bacterial outer membrane, is also known to activate host innate immunity via Toll-like receptor 2 (TLR2)-mediated signaling. The molecular mechanism of PorB binding to TLR2 is not known, but it has been hypothesize ...[more]