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Six new tetraprenylated alkaloids from the South China Sea gorgonian Echinogorgia pseudossapo.

ABSTRACT: Six new tetraprenylated alkaloids, designated as malonganenones L-Q (1-6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 1-6 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 1-6 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC?? values of 8.5 and 20.3 µM, respectively.

SUBMITTER: Sun ZH

PROVIDER: S-EPMC3944508 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Six new tetraprenylated alkaloids from the South China Sea gorgonian Echinogorgia pseudossapo.

Sun Zhang-Hua ZH Cai Ying-Hong YH Fan Cheng-Qi CQ Tang Gui-Hua GH Luo Hai-Bin HB Yin Sheng S

Marine drugs 20140127 2

Six new tetraprenylated alkaloids, designated as malonganenones L-Q (1-6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 1-6 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 1-6 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate ...[more]

PMID: 24473168

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