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Bioactive pregnane steroids from a South China Sea gorgonian Carijoa sp.


ABSTRACT: A new pregnane steroid, 1, and three known analogues 2-4, have been isolated from a gorgonian Carijoa sp. collected from the South China Sea. The planar structure and relative configuration of 1 were elucidated from comprehensive spectroscopic data. Its absolute configuration was determined by application of the modified Mosher method. Compounds 1, 3 and 4 exhibited cytotoxicity against the human hepatoma cell line Bel-7402, with IC50 values of 9.33, 11.02 and 18.68 µM, respectively. Additionally, compound 1 exhibited promising antibacterial activity against Pseudomona puido, with a MIC value of 31 nM, which is approximately 5-fold more potent than ciprofloxacin (MIC = 156 nM).

SUBMITTER: Zhao HY 

PROVIDER: S-EPMC6270022 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Bioactive pregnane steroids from a South China Sea gorgonian Carijoa sp.

Zhao Hong-Ying HY   Shao Chang-Lun CL   Li Zhi-Yong ZY   Han Lei L   Cao Fei F   Wang Chang-Yun CY  

Molecules (Basel, Switzerland) 20130315 3


A new pregnane steroid, 1, and three known analogues 2-4, have been isolated from a gorgonian Carijoa sp. collected from the South China Sea. The planar structure and relative configuration of 1 were elucidated from comprehensive spectroscopic data. Its absolute configuration was determined by application of the modified Mosher method. Compounds 1, 3 and 4 exhibited cytotoxicity against the human hepatoma cell line Bel-7402, with IC50 values of 9.33, 11.02 and 18.68 µM, respectively. Additionall  ...[more]

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