Ontology highlight
ABSTRACT:
SUBMITTER: Zhao HY
PROVIDER: S-EPMC6270022 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Zhao Hong-Ying HY Shao Chang-Lun CL Li Zhi-Yong ZY Han Lei L Cao Fei F Wang Chang-Yun CY
Molecules (Basel, Switzerland) 20130315 3
A new pregnane steroid, 1, and three known analogues 2-4, have been isolated from a gorgonian Carijoa sp. collected from the South China Sea. The planar structure and relative configuration of 1 were elucidated from comprehensive spectroscopic data. Its absolute configuration was determined by application of the modified Mosher method. Compounds 1, 3 and 4 exhibited cytotoxicity against the human hepatoma cell line Bel-7402, with IC50 values of 9.33, 11.02 and 18.68 µM, respectively. Additionall ...[more]