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Chemistry and Bioactivity of Briaranes from the South China Sea Gorgonian Dichotella gemmacea.


ABSTRACT: Seven new briarane diterpenoids, gemmacolides AZ-BF (1-7), were isolated together with eight known analogues (8-15) from the South China gorgonian Dichotella gemmacea. Their structures were elucidated based on detailed spectroscopic analysis and a comparison with reported data. In an in vitro bioassay, these compounds exhibited different levels of growth inhibition activity against A549 and MG63 cells, giving continuous evidences about the biological contribution of functional groups at C-2, C-12, C-13, and C-16. These compounds were also evaluated for their antibacterial and antifungal activities. Compound 8 exhibited a potential antibacterial activity against both Gram-positive bacterium Bacillus megaterium and Gram-negative bacterium Escherichia coli.

SUBMITTER: Li C 

PROVIDER: S-EPMC5128744 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Chemistry and Bioactivity of Briaranes from the South China Sea Gorgonian Dichotella gemmacea.

Li Cui C   La Ming-Ping MP   Tang Hua H   Sun Peng P   Liu Bao-Shu BS   Zhuang Chun-Lin CL   Yi Yang-Hua YH   Zhang Wen W  

Marine drugs 20161028 11


Seven new briarane diterpenoids, gemmacolides AZ-BF (<b>1</b>-<b>7</b>), were isolated together with eight known analogues (<b>8</b>-<b>15</b>) from the South China gorgonian <i>Dichotella gemmacea</i>. Their structures were elucidated based on detailed spectroscopic analysis and a comparison with reported data. In an in vitro bioassay, these compounds exhibited different levels of growth inhibition activity against A549 and MG63 cells, giving continuous evidences about the biological contributi  ...[more]

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