Ontology highlight
ABSTRACT:
SUBMITTER: Gabriel EE
PROVIDER: S-EPMC3944974 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Gabriel Erin E EE Gilbert Peter B PB
Biostatistics (Oxford, England) 20131213 2
Principal surrogate (PS) endpoints are relatively inexpensive and easy to measure study outcomes that can be used to reliably predict treatment effects on clinical endpoints of interest. Few statistical methods for assessing the validity of potential PSs utilize time-to-event clinical endpoint information and to our knowledge none allow for the characterization of time-varying treatment effects. We introduce the time-dependent and surrogate-dependent treatment efficacy curve, ${\mathrm {TE}}(t|s ...[more]