Ontology highlight
ABSTRACT:
SUBMITTER: Chin YR
PROVIDER: S-EPMC3946502 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Chin Y Rebecca YR Yoshida Taku T Marusyk Andriy A Beck Andrew H AH Polyak Kornelia K Toker Alex A
Cancer research 20131212 3
Triple-negative breast cancer (TNBC) is currently the only major breast tumor subtype without effective targeted therapy and, as a consequence, in general has a poor outcome. To identify new therapeutic targets in TNBC, we performed a short hairpin RNA (shRNA) screen for protein kinases commonly amplified and overexpressed in breast cancer. Using this approach, we identified AKT3 as a gene preferentially required for the growth of TNBCs. Downregulation of Akt3 significantly inhibits the growth o ...[more]