Ontology highlight
ABSTRACT:
SUBMITTER: Lu P
PROVIDER: S-EPMC3949569 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Lu Peiyuan P Youngblood Benjamin A BA Austin James W JW Mohammed Ata Ur Rasheed AU Butler Royce R Ahmed Rafi R Boss Jeremy M JM
The Journal of experimental medicine 20140303 3
Programmed cell death 1 (PD-1) is an inhibitory immune receptor that regulates T cell function, yet the molecular events that control its expression are largely unknown. We show here that B lymphocyte-induced maturation protein 1 (Blimp-1)-deficient CD8 T cells fail to repress PD-1 during the early stages of CD8 T cell differentiation after acute infection with lymphocytic choriomeningitis virus (LCMV) strain Armstrong. Blimp-1 represses PD-1 through a feed-forward repressive circuit by regulati ...[more]