Refractive index-based detection of gradient elution liquid chromatography using chip-integrated microring resonator arrays.

ABSTRACT: Refractive index-based sensors offer attractive characteristics as nondestructive and universal detectors for liquid chromatographic separations, but a small dynamic range and sensitivity to minor thermal perturbations limit the utility of commercial RI detectors for many potential applications, especially those requiring the use of gradient elutions. As such, RI detectors find use almost exclusively in sample abundant, isocratic separations when interfaced with high-performance liquid chromatography. Silicon photonic microring resonators are refractive index-sensitive optical devices that feature good sensitivity and tremendous dynamic range. The large dynamic range of microring resonators allows the sensors to function across a wide spectrum of refractive indices, such as that encountere

SUBMITTER: Wade JH 

PROVIDER: S-EPMC3950336 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature