Ontology highlight
ABSTRACT:
SUBMITTER: Pascoalino B
PROVIDER: S-EPMC3950673 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Pascoalino Bruno B Dindar Gülcin G Vieira-da-Rocha João P JP Machado Carlos Renato CR Janzen Christian J CJ Schenkman Sergio S
Nucleic acids research 20131209 5
The anti-silencing function protein 1 (Asf1) is a chaperone that forms a complex with histones H3 and H4 facilitating dimer deposition and removal from chromatin. Most eukaryotes possess two different Asf1 chaperones but their specific functions are still unknown. Trypanosomes, a group of early-diverged eukaryotes, also have two, but more divergent Asf1 paralogs than Asf1 of higher eukaryotes. To unravel possible different functions, we characterized the two Asf1 proteins in Trypanosoma brucei. ...[more]