Ontology highlight
ABSTRACT:
SUBMITTER: Galvani A
PROVIDER: S-EPMC2423286 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Galvani Angélique A Courbeyrette Régis R Agez Morgane M Ochsenbein Françoise F Mann Carl C Thuret Jean-Yves JY
Molecular and cellular biology 20080331 11
Histone chaperones have been implicated in nucleosome assembly and disassembly as well as histone modification. ASF1 is a highly conserved histone H3/H4 chaperone that synergizes in vitro with two other histone chaperones, chromatin assembly factor 1 (CAF-1) and histone repression A factor (HIRA), in DNA synthesis-coupled and DNA synthesis-independent nucleosome assembly. Here, we identify mutants of histones H3.1 and H3.3 that are unable to interact with human ASF1A and ASF1B isoforms but that ...[more]