Ontology highlight
ABSTRACT:
SUBMITTER: Simon B
PROVIDER: S-EPMC8826447 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Simon Bertrand B Lou Hua Jane HJ Huet-Calderwood Clotilde C Shi Guangda G Boggon Titus J TJ Turk Benjamin E BE Calderwood David A DA
Nature communications 20220208 1
Tousled-like kinases (TLKs) are nuclear serine-threonine kinases essential for genome maintenance and proper cell division in animals and plants. A major function of TLKs is to phosphorylate the histone chaperone proteins ASF1a and ASF1b to facilitate DNA replication-coupled nucleosome assembly, but how TLKs selectively target these critical substrates is unknown. Here, we show that TLK2 selectivity towards ASF1 substrates is achieved in two ways. First, the TLK2 catalytic domain recognizes cons ...[more]